When Virginia seceded from the Union in 1861, the northwestern counties seceded in turn from the state to form West Virginia.
While California hasn't seceded (yet), a similar dynamic is at work there in response to the state’s attempt at nullifying federal immigration law through "sanctuary" measures that prohibit public or private cooperation with immigration officers. The small city of Los Alamitos, in Orange County, voted last week to exempt itself from the state's sanctuary laws. On Monday, the Orange County Sheriff's Department announced it would publicly post the release dates of all inmates so that ICE can pick up those it wants as soon as they're released. And on Tuesday, the Orange County Board of Supervisors voted to join the U.S. Department of Justice lawsuit against the state's illegal-alien sanctuary laws.
More jurisdictions are likely to join the revolt in one way or another.